Studies Specifically with Lumega-Z
Bone, R., Davey, P., Roman, B., & Evans, D. (2020). Efficacy of Commercially Available Nutritional Supplements: Analysis of Serum Uptake, Macular Pigment Optical Density and Visual Functional Response. Nutrients, 12(5): 1321. doi: 10.3390/nu12051321
Lem, D., Henderson, T., Weiss, R., Evans, D., Amonoo-Monney, S., & Davey, P. (2019). Evaluation of visual functional changes in eyes with drusen using the Micronized Lipid-Based Carotenoid Liquid Supplementation and AREDS2 Formula. Investigative Ophthalmology & Visual Science, 60(9):36. Retrieved from https://iovs.arvojournals.org/
Carotenoids and Macular Pigment
Akuffo, K., Beatty, S., Stack, J., Dennison, J., O’Regan, S., Meagher, K., Peto, T., Nolan, J. (2014). Central Retinal Enrichment Supplementation Trials (CREST): Design and Methodology of the CREST Randomized Controlled Trials. Ophthalmic Epidemiol, 21(2):111-23. doi: 10.3109/09286586.2014.888085
Kelly, E., Plat, J., Haenen, G., Kijlstra, A., & Berendschot, T. (2014). The Effect of Modified Eggs and an Egg-Yolk Based Beverage on Serum Lutein and Zeaxanthin Concentrations and Macular Pigment Optical Density: Results from a Randomized Trial. PLoS One, 9(3): e92659. doi: 10.1371/journal.pone.0092659
Widomska, J., & Subczynski, W. (2014). Why has Nature Chosen Lutein and Zeaxanthin to Protect the Retina? J Clin Exp Ophthalmol, 5(1): 326. doi: 10.4172/2155-9570.1000326
Bone, R., & Mukherjee, A. (2013). Innovative Troxler-free Measurement of Macular Pigment and Lens Density With Correction of the Former for the Aging Lens. J Biomed Opt., 18(10):107003. doi: 10.1117/1.JBO.18.10.107003
Feeney, J., Finucane, C., Savva, G., Cronin, H., Beatty, S., Nolan, J., & Kenny, R. (2013). Low Macular Pigment Optical Density Is Associated With Lower Cognitive Performance in a Large, Population-Based Sample of Older Adults. Neurobiol Aging, 34(11):2449-56. doi: 10.1016/j.neurobiolaging.2013.05.007
Henriksen, B., Chan, G., Hoffman, R., Sharifzadeh, M., Ermakov, I., Gellermann, W., & Bernstein, P. (2013). Interrelationships Between Maternal Carotenoid Status and Newborn Infant Macular Pigment Optical Density and Carotenoid Status. Invest Ophthalmol Vis Sci., 54(8): 5568–5578. doi: 10.1167/iovs.13-12331
Nolan, J., Akkali, M., Loughman, J., Howard, A., & Beatty, S. (2012). Macular Carotenoid Supplementation in Subjects With Atypical Spatial Profiles of Macular Pigment. Exp Eye Res., 101:9-15. doi: 10.1016/j.exer.2012.05.006
Stringham, J., Garcia, P., Smith, P., McLin, L. & Foutch, B. (2011). Macular Pigment and Visual Performance in Glare: Benefits for Photostress Recovery, Disability Glare, and Visual Discomfort. Investigative Ophthalmology & Visual Science, 52(10):7406-7415. doi:https://doi.org/10.1167/iovs.10-6699
Connolly, E., Beatty, S., Thurnham, D., Loughman, J., Howard, A., Stack, J., & Nolan, J. (2010). Augmentation of Macular Pigment Following Supplementation With All Three Macular Carotenoids: An Exploratory Study. Curr Eye Res., 35(4):335-51. doi: 10.3109/02713680903521951
Li, B., Ahmed, F., & Bernstein, P. (2010). Studies on the Singlet Oxygen Scavenging Mechanism of Human Macular Pigment. Arch Biochem Biophys., 504(1):56-60. doi: 10.1016/j.abb.2010.07.024
Thurnham, D., Tre ́mel, A., & Howard, A. (2008). A supplementation study in human subjects with a combinationofmeso-zeaxanthin, (3R,30R)-zeaxanthin and (3R,30R,60R)-lutein. British Journal of Nutrition, 100:1307–1314. doi:10.1017/S0007114508971336
Bhosale, P., Zhao, D., & Bernstein, P. (2007). HPLC Measurement of Ocular Carotenoid Levels in Human Donor Eyes in the Lutein Supplementation Era. Investigative Ophthalmology & Visual Science, 48(2):543-9. doi: 10.1167/iovs.06-0558
Bone, R., Landrum, J., Cao, Y., Howard, A., & Alvarez-Calderon, F. (2007). Macular Pigment Response to a Supplement Containing Meso-Zeaxanthin, Lutein and Zeaxanthin. Nutr Metab (Lond), 11(4):12. doi: 10.1186/1743-7075-4-12
Bhosale, P., Zhao, D., & Bernstein, P. (2007). HPLC Measurement of Ocular Carotenoid Levels in Human Donor Eyes in the Lutein Supplementation Era. Investigative Ophthalmology & Visual Science, 48(2):543-9. doi: 10.1167/iovs.06-0558
Mares, J., LaRowe, T., Snodderly, D., Moeller, S., Gruber, M., Klein, M., Wooten, B., Johnson, E., Chappell, R., CAREDS Macular Pigment Study Group & Investigators (2006). Predictors of Optical Density of Lutein and Zeaxanthin in Retinas of Older Women in the Carotenoids in Age-Related Eye Disease Study, an Ancillary Study of the Women’s Health Initiative. Am J Clin Nutr., 84(5):1107-22. doi: 10.1093/ajcn/84.5.1107
Whitehead, J., Mares, J., & Danis, R. (2006). Macular Pigment. Arch Ophthalmol. 124(7):1038-1045. doi:10.1001/archopht.124.7.1038
Bone, R., Landrum, J., Guerra, L., & Ruiz, C. (2003). Lutein and Zeaxanthin Dietary Supplements Raise Macular Pigment Density and Serum Concentrations of These Carotenoids in Humans. J Nutr, 133(4):992-8. doi: 10.1093/jn/133.4.992
Krinsky, N., Landrum, J., & Bone, R. (2003). Biologic Mechanisms of the Protective Role of Lutein and Zeaxanthin in the Eye. Annu Rev Nutr., 23:171-201. doi: 10.1146/annurev.nutr.23.011702.073307
Wooten, B., & Hammond, B., (2002). Macular Pigment: Influences on Visual Acuity and Visibility. Prog Retin Eye Res., 21(2):225-40. doi: 10.1016/s1350-9462(02)00003-4
Beatty, S. Murray, I., Henson, D., Carden, D., Koh, H., & Boulton, M. (2001). Macular Pigment and Risk for Age-Related Macular Degeneration in Subjects From a Northern European Population. Invest Ophthalmol Vis Sci., 42(2):439-46. Retrieved from https://iovs.arvojournals.org/
Landrum, J., & Bone, R. (2001). Lutein, Zeaxanthin, and the Macular Pigment. Arch Biochem Biophys., 385(1):28-40. doi: 10.1006/abbi.2000.2171
Bone, R., Landrum, J., Friedes, L., Gomez, C., Kilburn, M., Menendez, E., Vidal, I., & Wang, W. (1997). Distribution of Lutein and Zeaxanthin Stereoisomers in the Human Retina. Exp Eye Res., 64(2):211-8. doi: 10.1006/exer.1996.0210
Bone, R., Landrum, J., Hime, G., Cains, A., & Zamor, J. (1993). Stereochemistry of the Human Macular Carotenoids. Invest Ophthalmol Vis Sci., 34(6):2033-40. Retrieved from https://iovs.arvojournals.org/
Carotenoids and Macular Degeneration
Meyers, K., Mares, J., Igo, R., Jr., Truitt, B., Liu, Z., Millen, A., Klein, M., Johnson, E., Engelman, C., Karki, C., Blodi, B., Gehrs, K., Tinker, L., Wallace, R., Robinson, J., LeBlanc, E., Sarto, G., Bernstein, P., SanGiovanni, J., & Iyengar, S. (2014). Genetic Evidence for Role of Carotenoids in Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). Invest Ophthalmol Vis Sci., 55(1):587–599. doi: 10.1167/iovs.13-13216
Pinazo-Durán, M., Gómez-Ulla, F., Arias, L., Araiz, J., Casaroli-Marano, R., Gallego-Pinazo, R., García-Medina, J., López-Gálvez, M., Manzanas, L., Salas, A., Zapata, M., Diaz-Llopis, M., & García-Layana, A. (2014). Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention? Journal of Ophthalmology, 14:901686. doi: 10.1155/2014/901686
Sabour-Pickett, S., Beatty, S., Connolly, E., Loughman, J., Stack, J., Howard, A., Klein, R., Klein, B., Meuer, S., Myers, C., Akuffo, K., & Nolan, J. (2014). Supplementation With Three Different Macular Carotenoid Formulations in Patients With Early Age-Related Macular Degeneration. Retina, 34(9):1757-66. doi: 10.1097/IAE.0000000000000174
Ma, L., Yan, S., Huang, Y., Lu, X., Qian, F., Pang, H., Xu, X., Zou, Z., Dong, P., Xiao, X., Wang, X., Sun, T., Dou, H., & Lin, X. (2012). Effect of Lutein and Zeaxanthin on Macular Pigment and Visual Function in Patients with Early Age-related Macular Degeneration. Ophthalmology, 119(11):2290-2297. doi:https://doi.org/10.1016/j.ophtha.2012.06.014
Sasaki, M., Yuki, K., Kurihara, T., Miyake, S., Noda, K., Kobayashi, S., Ishida, S., Tsubota, K., & Ozawa, Y. (2012). Biological Role of Lutein in the Light-Induced Retinal Degeneration. J Nutr Biochem., 23(5):423-9. doi: 10.1016/j.jnutbio.2011.01.006
Sabour-Pickett, S., Nolan, J., Loughman, J., & Beatty, S. (2012). A Review of the Evidence Germane to the Putative Protective Role of the Macular Carotenoids for Age-Related Macular Degeneration. Mol Nutr Food Res., 56(2):270-86. doi: 10.1002/mnfr.201100219
Bernstein, P., Delori, F., Richer, S., Kuijk, F., & Wenzel, A. (2010). The Value of Measurement of Macular Carotenoid Pigment Optical Densities and Distributions in Age-Related Macular Degeneration and Other Retinal Disorders. Vision Res., 50(7): 716–728. doi: 10.1016/j.visres.2009.10.014
Landrum, J., & Bone, R. (2004). Dietary lutein and zeaxanthin: reducing the risk for macular degeneration. Agro Food Ind. Hi-Tech, 15:22–25. Retrieved from https://www.teknoscienze.com/agro-food-industry/
Vitamins, Minerals, Macular Degeneration and General Health
Shardell, M., Alley, D., Hicks, G., El-Kamary, S., Miller, R., Semba, R., & Ferrucci, L. (2011). Low serum carotenoid concentrations and carotenoidinteractions predict mortality in US adults: The Third NationalHealth and Nutrition Examination Survey (NHANES III). Nutr Res., 31(3): 178–189. doi:10.1016/j.nutres.2011.03.003
Moeller, S., Voland, R., Tinker, L., Blodi, B., Klein, M., Gehrs, K., Johnson, E., Snodderly, D., Wallace, R., Chappell, R., Parekh, N., Ritenbaugh, C., Mares, J., & the CAREDS Study Group (2008). Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in Age-Related Eye Disease Study (CAREDS), an ancillary study of the Women’s Health Initiative. Arch Ophthalmol., 126(3): 354–364. doi: 10.1001/archopht.126.3.354
Chasan-Taber, L., Willett, W., Seddon, J., Stampfer, M., Rosner, B., Colditz, G., Speizer, F., & Hankinson, S. (1999). A Prospective Study of Carotenoid and Vitamin A Intakes and Risk of Cataract Extraction in US Women. Am J Clin Nutr., 70(4):509-16. doi: 10.1093/ajcn/70.4.509
Brown, N., Bron, A., Harding, J., & Dewar, H. (1998). Nutrition Supplements and the Eye. Eye (Lond)., 12 (1):127-33. doi: 10.1038/eye.1998.21
Evans, J., & Henshaw, K. (2008). Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. The Cochrane database of systematic reviews (1). CD000253. ISSN 1469- 493X doi: 10.1002/14651858.CD000253.pub2
