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The Only Vision-Specific Medical Food, contains
all three Macular Carotenoids

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Studies Specifically with Lumega-Z

Bone, R., Davey, P., Roman, B., & Evans, D. (2020). Efficacy of Commercially Available Nutritional Supplements: Analysis of Serum Uptake, Macular Pigment Optical Density and Visual Functional Response. Nutrients, 12(5): 1321. doi: 10.3390/nu12051321

Lem, D., Henderson, T., Weiss, R., Evans, D., Amonoo-Monney, S., & Davey, P. (2019). Evaluation of visual functional changes in eyes with drusen using the Micronized Lipid-Based Carotenoid Liquid Supplementation and AREDS2 Formula. Investigative Ophthalmology & Visual Science, 60(9):36. Retrieved from https://iovs.arvojournals.org/

Carotenoids and Macular Pigment

Akuffo, K., Beatty, S., Stack, J., Dennison, J., O’Regan, S., Meagher, K., Peto, T., Nolan, J. (2014). Central Retinal Enrichment Supplementation Trials (CREST): Design and Methodology of the CREST Randomized Controlled Trials. Ophthalmic Epidemiol, 21(2):111-23. doi: 10.3109/09286586.2014.888085

Kelly, E., Plat, J., Haenen, G., Kijlstra, A., & Berendschot, T. (2014). The Effect of Modified Eggs and an Egg-Yolk Based Beverage on Serum Lutein and Zeaxanthin Concentrations and Macular Pigment Optical Density: Results from a Randomized Trial. PLoS One, 9(3): e92659. doi: 10.1371/journal.pone.0092659

Widomska, J., & Subczynski, W. (2014). Why has Nature Chosen Lutein and Zeaxanthin to Protect the Retina? J Clin Exp Ophthalmol, 5(1): 326. doi: 10.4172/2155-9570.1000326

Bone, R., & Mukherjee, A. (2013). Innovative Troxler-free Measurement of Macular Pigment and Lens Density With Correction of the Former for the Aging Lens. J Biomed Opt., 18(10):107003. doi: 10.1117/1.JBO.18.10.107003

Feeney, J., Finucane, C., Savva, G., Cronin, H., Beatty, S., Nolan, J., & Kenny, R. (2013). Low Macular Pigment Optical Density Is Associated With Lower Cognitive Performance in a Large, Population-Based Sample of Older Adults. Neurobiol Aging, 34(11):2449-56. doi: 10.1016/j.neurobiolaging.2013.05.007

Henriksen, B., Chan, G., Hoffman, R., Sharifzadeh, M., Ermakov, I., Gellermann, W., & Bernstein, P. (2013). Interrelationships Between Maternal Carotenoid Status and Newborn Infant Macular Pigment Optical Density and Carotenoid Status. Invest Ophthalmol Vis Sci., 54(8): 5568–5578. doi: 10.1167/iovs.13-12331

Nolan, J., Akkali, M., Loughman, J., Howard, A., & Beatty, S. (2012). Macular Carotenoid Supplementation in Subjects With Atypical Spatial Profiles of Macular Pigment. Exp Eye Res., 101:9-15. doi: 10.1016/j.exer.2012.05.006

Stringham, J., Garcia, P., Smith, P., McLin, L. & Foutch, B. (2011). Macular Pigment and Visual Performance in Glare: Benefits for Photostress Recovery, Disability Glare, and Visual Discomfort. Investigative Ophthalmology & Visual Science, 52(10):7406-7415. doi:https://doi.org/10.1167/iovs.10-6699

Connolly, E., Beatty, S., Thurnham, D., Loughman, J., Howard, A., Stack, J., & Nolan, J. (2010). Augmentation of Macular Pigment Following Supplementation With All Three Macular Carotenoids: An Exploratory Study. Curr Eye Res., 35(4):335-51. doi: 10.3109/02713680903521951

Li, B., Ahmed, F., & Bernstein, P. (2010). Studies on the Singlet Oxygen Scavenging Mechanism of Human Macular Pigment. Arch Biochem Biophys., 504(1):56-60. doi: 10.1016/j.abb.2010.07.024

Thurnham, D., Tre ́mel, A., & Howard, A. (2008). A supplementation study in human subjects with a combinationofmeso-zeaxanthin, (3R,30R)-zeaxanthin and (3R,30R,60R)-lutein. British Journal of Nutrition, 100:1307–1314. doi:10.1017/S0007114508971336

Bhosale, P., Zhao, D., & Bernstein, P. (2007). HPLC Measurement of Ocular Carotenoid Levels in Human Donor Eyes in the Lutein Supplementation Era. Investigative Ophthalmology & Visual Science, 48(2):543-9. doi: 10.1167/iovs.06-0558

Bone, R., Landrum, J., Cao, Y., Howard, A., & Alvarez-Calderon, F. (2007). Macular Pigment Response to a Supplement Containing Meso-Zeaxanthin, Lutein and Zeaxanthin. Nutr Metab (Lond), 11(4):12. doi: 10.1186/1743-7075-4-12

Bhosale, P., Zhao, D., & Bernstein, P. (2007). HPLC Measurement of Ocular Carotenoid Levels in Human Donor Eyes in the Lutein Supplementation Era. Investigative Ophthalmology & Visual Science, 48(2):543-9. doi: 10.1167/iovs.06-0558

Mares, J., LaRowe, T., Snodderly, D., Moeller, S., Gruber, M., Klein, M., Wooten, B., Johnson, E., Chappell, R., CAREDS Macular Pigment Study Group & Investigators (2006). Predictors of Optical Density of Lutein and Zeaxanthin in Retinas of Older Women in the Carotenoids in Age-Related Eye Disease Study, an Ancillary Study of the Women’s Health Initiative. Am J Clin Nutr., 84(5):1107-22. doi: 10.1093/ajcn/84.5.1107

Whitehead, J., Mares, J., & Danis, R. (2006). Macular Pigment. Arch Ophthalmol. 124(7):1038-1045. doi:10.1001/archopht.124.7.1038

Bone, R., Landrum, J., Guerra, L., & Ruiz, C. (2003). Lutein and Zeaxanthin Dietary Supplements Raise Macular Pigment Density and Serum Concentrations of These Carotenoids in Humans. J Nutr, 133(4):992-8. doi: 10.1093/jn/133.4.992

Krinsky, N., Landrum, J., & Bone, R. (2003). Biologic Mechanisms of the Protective Role of Lutein and Zeaxanthin in the Eye. Annu Rev Nutr., 23:171-201. doi: 10.1146/annurev.nutr.23.011702.073307

Wooten, B., & Hammond, B., (2002). Macular Pigment: Influences on Visual Acuity and Visibility. Prog Retin Eye Res., 21(2):225-40. doi: 10.1016/s1350-9462(02)00003-4

Beatty, S. Murray, I., Henson, D., Carden, D., Koh, H., & Boulton, M. (2001). Macular Pigment and Risk for Age-Related Macular Degeneration in Subjects From a Northern European Population. Invest Ophthalmol Vis Sci., 42(2):439-46. Retrieved from https://iovs.arvojournals.org/

Landrum, J., & Bone, R. (2001). Lutein, Zeaxanthin, and the Macular Pigment. Arch Biochem Biophys., 385(1):28-40. doi: 10.1006/abbi.2000.2171

Bone, R., Landrum, J., Friedes, L., Gomez, C., Kilburn, M., Menendez, E., Vidal, I., & Wang, W. (1997). Distribution of Lutein and Zeaxanthin Stereoisomers in the Human Retina. Exp Eye Res., 64(2):211-8. doi: 10.1006/exer.1996.0210

Bone, R., Landrum, J., Hime, G., Cains, A., & Zamor, J. (1993). Stereochemistry of the Human Macular Carotenoids. Invest Ophthalmol Vis Sci., 34(6):2033-40. Retrieved from https://iovs.arvojournals.org/

Carotenoids and Macular Degeneration

Meyers, K., Mares, J., Igo, R., Jr., Truitt, B., Liu, Z., Millen, A., Klein, M., Johnson, E., Engelman, C., Karki, C., Blodi, B., Gehrs, K., Tinker, L., Wallace, R., Robinson, J., LeBlanc, E., Sarto, G., Bernstein, P., SanGiovanni, J., & Iyengar, S. (2014). Genetic Evidence for Role of Carotenoids in Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). Invest Ophthalmol Vis Sci., 55(1):587–599. doi: 10.1167/iovs.13-13216

Pinazo-Durán, M., Gómez-Ulla, F., Arias, L., Araiz, J., Casaroli-Marano, R., Gallego-Pinazo, R., García-Medina, J., López-Gálvez, M., Manzanas, L., Salas, A., Zapata, M., Diaz-Llopis, M., & García-Layana, A. (2014). Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention? Journal of Ophthalmology, 14:901686. doi: 10.1155/2014/901686

Sabour-Pickett, S., Beatty, S., Connolly, E., Loughman, J., Stack, J., Howard, A., Klein, R., Klein, B., Meuer, S., Myers, C., Akuffo, K., & Nolan, J. (2014). Supplementation With Three Different Macular Carotenoid Formulations in Patients With Early Age-Related Macular Degeneration. Retina, 34(9):1757-66. doi: 10.1097/IAE.0000000000000174

Ma, L., Yan, S., Huang, Y., Lu, X., Qian, F., Pang, H., Xu, X., Zou, Z., Dong, P., Xiao, X., Wang, X., Sun, T., Dou, H., & Lin, X. (2012). Effect of Lutein and Zeaxanthin on Macular Pigment and Visual Function in Patients with Early Age-related Macular Degeneration. Ophthalmology, 119(11):2290-2297. doi:https://doi.org/10.1016/j.ophtha.2012.06.014

Sasaki, M., Yuki, K., Kurihara, T., Miyake, S., Noda, K., Kobayashi, S., Ishida, S., Tsubota, K., & Ozawa, Y. (2012). Biological Role of Lutein in the Light-Induced Retinal Degeneration. J Nutr Biochem., 23(5):423-9. doi: 10.1016/j.jnutbio.2011.01.006

Sabour-Pickett, S., Nolan, J., Loughman, J., & Beatty, S. (2012). A Review of the Evidence Germane to the Putative Protective Role of the Macular Carotenoids for Age-Related Macular Degeneration. Mol Nutr Food Res., 56(2):270-86. doi: 10.1002/mnfr.201100219

Bernstein, P., Delori, F., Richer, S., Kuijk, F., & Wenzel, A. (2010). The Value of Measurement of Macular Carotenoid Pigment Optical Densities and Distributions in Age-Related Macular Degeneration and Other Retinal Disorders. Vision Res., 50(7): 716–728. doi: 10.1016/j.visres.2009.10.014

Landrum, J., & Bone, R. (2004). Dietary lutein and zeaxanthin: reducing the risk for macular degeneration. Agro Food Ind. Hi-Tech, 15:22–25. Retrieved from https://www.teknoscienze.com/agro-food-industry/

Vitamins, Minerals,  Macular Degeneration and General Health

Shardell, M., Alley, D., Hicks, G., El-Kamary, S., Miller, R., Semba, R., & Ferrucci, L. (2011). Low serum carotenoid concentrations and carotenoidinteractions predict mortality in US adults: The Third NationalHealth and Nutrition Examination Survey (NHANES III). Nutr Res., 31(3): 178–189. doi:10.1016/j.nutres.2011.03.003

Moeller, S., Voland, R., Tinker, L., Blodi, B., Klein, M., Gehrs, K., Johnson, E., Snodderly, D., Wallace, R., Chappell, R., Parekh, N., Ritenbaugh, C., Mares, J., & the CAREDS Study Group (2008). Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in Age-Related Eye Disease Study (CAREDS), an ancillary study of the Women’s Health Initiative. Arch Ophthalmol., 126(3): 354–364. doi: 10.1001/archopht.126.3.354

Chasan-Taber, L., Willett, W., Seddon, J., Stampfer, M., Rosner, B., Colditz, G., Speizer, F., & Hankinson, S. (1999). A Prospective Study of Carotenoid and Vitamin A Intakes and Risk of Cataract Extraction in US Women. Am J Clin Nutr., 70(4):509-16. doi: 10.1093/ajcn/70.4.509

Brown, N., Bron, A., Harding, J., & Dewar, H. (1998). Nutrition Supplements and the Eye. Eye (Lond)., 12 (1):127-33. doi: 10.1038/eye.1998.21

Evans, J., & Henshaw, K. (2008). Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. The Cochrane database of systematic reviews (1). CD000253. ISSN 1469- 493X doi: 10.1002/14651858.CD000253.pub2


How Lumega Z Works

Learn about the macular pigment and how important it is for ocular health and staving off eye diseases, such as macular degeneration. Also learn how Medical Foods, which include carotenoids, can restore the macular pigment.


Dr. Hovenesian

Watch as Dr. Hovenesian, a recognized ophthalmology expert in eye disease and eye health, describes why Lumega-Z is so special and why he prescribes it to his patients.

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Lumega-­Z is the only Medical Food created to replenish and restore the Macular Pigment.

28 day supply: 4 x 5.25 FL OZ with 60 Soft Gels

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Lumega-Z is a Medical Food. In order to process your order, you will need a DAC (Doctor Authorization Code) number from your healthcare provider. If you do not have a DAC number, please call us at (800) 873-5141 (Ext. 1) so that we may assist you.

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